Tetracycline resistance mediated by ribosomal protection.
نویسندگان
چکیده
Resistance to tetracycline may be mediated by one of three different mechanisms: (i) an energy-dependent efflux of tetracycline brought about by an integral membrane protein (20); (ii) ribosomal protection by a soluble protein (5, 23), or (iii) enzymatic inactivation of tetracycline (33), which occurs rarely. This minireview concentrates exclusively on the second mechanism of tetracycline resistance.
منابع مشابه
Host mutations (miaA and rpsL) reduce tetracycline resistance mediated by Tet(O) and Tet(M).
The effects of mutations in host genes on tetracycline resistance mediated by the Tet(O) and Tet(M) ribosomal protection proteins, which originated in Campylobacter spp. and Streptococcus spp., respectively, were investigated by using mutants of Salmonella typhimurium and Escherichia coli. The miaA, miaB, and miaAB double mutants of S. typhimurium specify enzymes for tRNA modification at the ad...
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The tetracyclines are a group of broad-spectrum antibiotics which were discovered in 1948 following the isolation of chlortetracycline from Streptomyces aureofaciens (4). Later, other tetracyclines (Table 1) were identified; they were either naturally occurring molecules (tetracycline, demethylchlortetracycline) or products of semisynthetic approaches (doxycycline, minocycline) (4). The tetracy...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 40 1 شماره
صفحات -
تاریخ انتشار 1996